* contributed equally


Alves S.*, Bode J.*, Bemelmans A.P., von Kalle C., Cartier N.* and Tews B.* Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain. Sci Rep.


Breckwoldt M.O.*, Bode J.*, Kurz F.T., Hoffmann A., Ochs K., Ott M., Deumelandt K., Krüwel T., Schwarz D., Fischer M., Helluy X., Milford D., Kirschbaum K., Solecki G., Chiblak S., Abdollahi A., Winkler F., Wick W., Platten M., Heiland S., Bendszus M.* and Tews B.* Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis. eLIFE.

Thiede-Stan N.K., Tews B., Albrecht D., Ristic Z., Ewers H. and Schwab M.E. Tetraspanin-3 is an organizer of the multi-subunit Nogo-A signaling complex. Journal of Cell Science.


Vajda F., Jordi N., Dalkara D., Joly S., Christ F., Tews B., Schwab M.E. and Pernet V. Cell type-specific Nogo-A gene ablation promotes axonal regeneration in the injured adult optic nerve. Cell Death and Differentiation.

Petrasek T., Prokopova I., Sladek M., Weissova K., Vojtechova I., Bahnik S., Zemanova A., Schönig K., Berger S., Tews B., Bartsch D., Schwab ME., Sumova A. and Stuchlik A. Nogo-A-deficient Transgenic Rats Show Deficits in Higher Cognitive Functions, Decreased Anxiety, and Altered Circadian Activity Patterns. Frontiers in Behavioral Neuroscience.

Enkel T., Berger SM., Schönig K., Tews B. and Bartsch D. Reduced expression of nogo-a leads to motivational deficits in rats. Frontiers in Behavioral Neuroscience.

Kempf A.*, Tews B.*, Arzt ME., Weinmann O., Obermair FJ., Pernet V., Zagrebelsky M., Delekate A., Iobbi C., Zemmar A., Ristic Z., Gullo M., Spies P., Dodd D., Gygax D., Korte M. and Schwab ME. The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity. PLoS Biology. Article recommended by Faculty of 1000.

Petrasek T., Prokopova I., Bahnik S., Schönig K., Berger S., Vales K., Tews B., Schwab ME., Bartsch D. and Stuchlik A. Nogo-A downregulation impairs place avoidance in the Carousel maze but not spatial memory in the Morris water maze. Neurobiology of Learning and Memory.


Kristofikova Z., Vrajova M., Sirova J., Vales K., Petrasek T., Schönig K., Tews B., Schwab ME., Bartsch D., Stuchlik A. and Ripova D. N-methyl-D-aspartate receptor – nitric oxide synthase pathway in the cortex of Nogo-A-deficient rats in relation to brain laterality and schizophrenia. Frontiers in Behavioral Neuroscience.

Wiestler B., Claus R., Hartlieb SA., Schliesser MG., Weiss EK., Hielscher T., Platten M., Dittmann LM., Meisner C., Felsberg J., Happold C., Simon M., Nikkhah G., Papsdorf K., Steinbach JP., Sabel M., Grimm C., Weichenhan D., Tews B., Reifenberger G., Capper D., Müller W., Plass C., Weller M. and Wick W.; for the Neuro-oncology Working Group (NOA) of the German Cancer Society. Malignant astrocytomas of elderly patients lack favorable molecular markers: an analysis of the NOA-08 study collective. Neuro Oncology.

Tews B.*, Schönig K.*, Arzt ME., Clementi S., Rioult-Pedotti MS., Zemmar A., Berger SM., Schneider M., Enkel T., Weinmann O., Kasper H., Schwab ME. and Bartsch D. Synthetic microRNA-mediated downregulation of Nogo-A in transgenic rats reveals its role as regulator of synaptic plasticity and cognitive function. Proceedings of the National Academy of Sciences USA.


Dittmann LM.*, Danner A.*, Gronych J., Wolter M., Stühler K., Grzendowski M., Becker N., Bageritz, J., Goidts, V., Tödt G., Felsberg J., Sabel M., Barbus S., Reifenberger G., Lichter P., Hahn M. and Tews B. Down-regulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumors and increases radio- and chemosensitivity of Hs683 glioma cells in vitro. Oncogene.


Weber T., Schönig K., Tews B. and Bartsch D. Inducible gene manipulations in brain serotonergic neurons of transgenic rats. PLoS One.

Tews B.*, Barbus S.*, Karra D., Hahn M., Radlwimmer B., Hartmann C,, Felsberg J., Krex D., Schackert G., Martinez R., Reifenberger G. and Lichter P. Retinoic acid signaling activates different targets in the tumors of long-term compared to short-term survivors of glioblastoma. Journal of the National Cancer Institute.


Toedt G., Barbus S., Wolter M., Felsberg J., Tews B., Blond F., Sabel M.C., Hofmann S., Becker N., Hartmann C., Ohgaki H., von Deimling A., Wiestler O.D., Hahn M., Lichter P., Reifenberger G. and Radlwimmer B. Molecular signatures classify astrocytic gliomas by IDH1 mutation status. International Journal of Cancer.


Löffler H., Bochtler T., Fritz B., Tews B., Ho A.D., Lukas J., Bartek J. and Krämer A. DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function. Cell Cycle.

Kunitz A., Wolter M., van den Boom J., Felsberg J., Tews B., Hahn M., Benner A., Sabel M., Lichter P., Reifenberger G., von Deimling A. and Hartmann C. DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in Human Gliomas. Brain Pathology.


Tews B.*, Roerig P.*, Hartmann C., Hahn M., Felsberg J., Blaschke B., Sabel M., Kunitz A., Toedt G., Neben K., Benner A., von Deimling A., Reifenberger G. and Lichter P. Hypermethylation and transcriptional down-regulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q. Oncogene.

Neben K., Ott G., Schweizer S., Kalla J., Tews B., Katzenberger T., Hahn M., Rosenwald A., Ho A.D., Müller-Hermelink H., Lichter P. and Krämer A. Expression of centrosome-associated gene products is linked to tetraploidization in mantle cell lymphoma. International Journal of Cancer.

Tews B., Felsberg J., Hartmann C., Kunitz A., Hahn M., Toedt G., Neben K., Hummerich L., von Deimling A., Reifenberger G. and Lichter P. Identification of novel oligodendroglioma-associated candidate tumor suppressor genes in 1p36 and 19q13 using microarray-based expression profiling. International Journal of Cancer.

Thuerigen O., Schneeweiss A., Toedt G., Warnat P., Hahn M., Kramer H., Brors B., Rudlowski C., Benner A., Schuetz F., Tews B., Eils R., Sinn H.P., Sohn C. and Lichter P. Gene expression signature predicting pathologic complete response to primary systemic chemotherapy with gemcitabine, epirubicin and docetaxel in primary breast cancer. Journal of Clinical Oncology.


Neben K., Schnittger S., Brors B., Tews B., Kokocinski F., Haferlach T., Muller J., Hahn M., Hiddemann W., Eils R., Lichter P. and Schoch C. Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotype. Oncogene.


Neben K., Tews B., Wrobel G., Hahn M., Kokocinski F., Giesecke C., Krause U., Ho A. D., Kramer A., and Lichter P. Gene expression patterns in acute myeloid leukemia correlate with centrosome aberrations and numerical chromosome changes. Oncogene.

Reuter H., Tews B., Wilhelm J. and Hahn M. Quantitative chimerism analysis by allele-specific real-time PCR of a 10 bp insertion/deletion polymorphism within the promoter region of factor VIIc. In: Wittwer, C., Hahn, M., Kaul, K. (Eds.): Rapid Cycle Real-Time PCR, Methods and Applications: Quantification. Springer, Berlin, Heidelberg, New York.


Korshunov A., Neben K., Wrobel G., Tews B., Benner A., Hahn M., Golanov A. and Lichter P. Gene expression patterns in ependymomas correlate with tumor location, grade, and patient age. American Journal of Pathology.

Tews B., Wilhelm J., Summerer D., Strerath M., Marx A., Friedhoff P., Pingoud A. and Hahn M. Application of the C4′-alkylated deoxyribose primer system (CAPS) in allele-specific real-time PCR for increased selectivity in discrimination of single nucleotide sequence variants. The Journal of Biological Chemistry.


Wilhelm J., Reuter H., Tews B., Pingoud A. and Hahn M. Detection and quantification of insertion/deletion variations by allele-specific real-time PCR: Application for genotyping and chimerism analysis. The Journal of Biological Chemistry.



Schwab ME., Tews B. and Kempf A. (2012). Blockers of the NOGO-A S1PR pathway for the treatment of diseases characterized by neuronal damage and lack of subsequent repair (WO2012164103).

Tews B., Roerig P., Hahn M., Hartmann C., Felsberg J., von Deimling A., Reifenberger G. and Lichter P. (2005). CITED4 as prognostic marker in oligodendroglial tumors. EP20050026117.

Marx A., Tews B., Wilhelm J., Friedhoff P., Hahn M. and Pingoud A. (2002). Verbessertes Verfahren zur allelspezifischen PCR. PCT Nr. 21139 EP-HIL.